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EMD-46606
Cryo-EM structure of BG505 DS-SOSIP.664 with 2 CH103 KN Fabs bound
EMD-46606
Single-particle3.68 Å
Deposition: 16/08/2024Map released: 04/06/2025
Last modified: 20/08/2025
Sample Organism:
Human immunodeficiency virus 1,
Homo sapiens
Sample: BG505 HIV-1 Env with 2 CH103 K75 N76 Fabs bound
Fitted models: 9d7i
Deposition Authors: Parsons RJ, Acharya P
Sample: BG505 HIV-1 Env with 2 CH103 K75 N76 Fabs bound
Fitted models: 9d7i
Deposition Authors: Parsons RJ, Acharya P
Acquisition of quaternary trimer interaction as a key step in the lineage maturation of a broad and potent HIV-1 neutralizing antibody.
Liu Q,
Parsons RJ,
Wiehe K,
Edwards RJ 
,
Saunders KO,
Zhang P,
Miao H,
Tilahun K,
Jones J,
Chen Y,
Hora B,
Williams WB,
Easterhoff D,
Huang X,
Janowska K,
Mansouri K,
Haynes BF,
Acharya P,
Lusso P
(2025) Structure , 33 , 1325 - 1336.e5
,
Saunders KO,
Zhang P,
Miao H,
Tilahun K,
Jones J,
Chen Y,
Hora B,
Williams WB,
Easterhoff D,
Huang X,
Janowska K,
Mansouri K,
Haynes BF,
Acharya P,
Lusso P
(2025) Structure , 33 , 1325 - 1336.e5
Grant Support:
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): R01 AI145687 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): U54 AI170752 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): U01 AI169587 (United States)