EMD-46598
Human-yeast chimeric Sec complex bound to KZR-261 inhibitor
EMD-46598
Single-particle3.0 Å
Deposition: 15/08/2024Map released: 25/06/2025
Last modified: 30/07/2025
Sample Organism:
Homo sapiens
Sample: Human-yeast chimeric Sec complex
Deposition Authors: Park E
,
Wang L
Sample: Human-yeast chimeric Sec complex
Deposition Authors: Park E
,
Wang L
Preclinical characterization of novel multi-client inhibitors of Sec61 with broad antitumor activity.
Lowe E,
Anderl JL ,
Bade D,
Delgado-Martin C,
Dong C,
Fan RA,
Fang Y,
Jiang J,
Johnson HWB,
Kempema A,
McGilvray P,
McMinn D,
Millare B,
Muchamuel T,
Poweleit N,
Qian Y,
Rehan S,
Scapin G,
Sugahara A,
Tranter D,
Tuch B,
Wang J,
Wang L ,
Whang JA,
Zuno-Mitchell P,
Paavilainen VO,
Park E ,
Taunton J,
Kirk CJ,
Anand NK
(2025) J Pharmacol Exp Ther , 392 , 103634 - 103634
,
Bade D,
Delgado-Martin C,
Dong C,
Fan RA,
Fang Y,
Jiang J,
Johnson HWB,
Kempema A,
McGilvray P,
McMinn D,
Millare B,
Muchamuel T,
Poweleit N,
Qian Y,
Rehan S,
Scapin G,
Sugahara A,
Tranter D,
Tuch B,
Wang J,
Wang L ,
Whang JA,
Zuno-Mitchell P,
Paavilainen VO,
Park E ,
Taunton J,
Kirk CJ,
Anand NK
(2025) J Pharmacol Exp Ther , 392 , 103634 - 103634
Grant Support:
- Other private: (United States)