Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-46597
Human Sec61 complex inhibited by KZR-261
EMD-46597
Single-particle3.1 Å
Deposition: 15/08/2024Map released: 23/07/2025
Last modified: 30/07/2025
Sample Organism:
Homo sapiens
Sample: Human-yeast chimeric Sec complex
Fitted models: 9d6l
Deposition Authors: Park E
,
Wang L
Sample: Human-yeast chimeric Sec complex
Fitted models: 9d6l
Deposition Authors: Park E
,
Wang L
Preclinical characterization of novel multi-client inhibitors of Sec61 with broad antitumor activity.
Lowe E,
Anderl JL ,
Bade D,
Delgado-Martin C,
Dong C,
Fan RA,
Fang Y,
Jiang J,
Johnson HWB,
Kempema A,
McGilvray P,
McMinn D,
Millare B,
Muchamuel T,
Poweleit N,
Qian Y,
Rehan S,
Scapin G,
Sugahara A,
Tranter D,
Tuch B,
Wang J,
Wang L,
Whang JA,
Zuno-Mitchell P,
Paavilainen VO,
Park E ,
Taunton J,
Kirk CJ,
Anand NK
(2025) J Pharmacol Exp Ther , 392 , 103634 - 103634
,
Bade D,
Delgado-Martin C,
Dong C,
Fan RA,
Fang Y,
Jiang J,
Johnson HWB,
Kempema A,
McGilvray P,
McMinn D,
Millare B,
Muchamuel T,
Poweleit N,
Qian Y,
Rehan S,
Scapin G,
Sugahara A,
Tranter D,
Tuch B,
Wang J,
Wang L,
Whang JA,
Zuno-Mitchell P,
Paavilainen VO,
Park E ,
Taunton J,
Kirk CJ,
Anand NK
(2025) J Pharmacol Exp Ther , 392 , 103634 - 103634
Grant Support:
- Other private: (United States)