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EMD-46464

Single-particle
2.95 Å
EMD-46464
3D View Gallery
Deposition: 07/08/2024
Map released: 16/04/2025
Last modified: 30/04/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-46464
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9d0w summary report (pdf.gz) Map and 9d0w FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of CDK2/CyclinE1 in complex with CRBN/DDB1 and Cpd 4

EMD-46464

Single-particle
2.95 Å
EMD-46464
3D View Gallery
Deposition: 07/08/2024
Map released: 16/04/2025
Last modified: 30/04/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Cryo-EM structure of CDK2/CyclinE1 in complex with CRBN/DDB1 and Cpd 4
Fitted models: 9d0w

Deposition Authors: Kwiatkowski N, Liang T, Sha Z, Collier PN, Yang A, Sathappa M, Paul A, Su L, Zheng X, Aversa R, Li K, Mehovic R, Breitkopf SB, Chen D, Howarth CL, Yuan K, Jo H, Growney JD, Weiss M, Williams J
CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers.
Kwiatkowski N, Liang T, Sha Z, Collier PN, Yang A, Sathappa M, Paul A, Su L, Zheng X, Aversa R, Li K, Mehovic R, Kolodzy C, Breitkopf SB, Chen D, Howarth CL, Yuan K, Jo H, Growney JD, Weiss M, Williams J
(2025) Cell Chem Biol , 32 , 556 - 569.e24
PUBMED: 40250405
DOI: doi:10.1016/j.chembiol.2025.03.006
ISSN: 2451-9456
Grant Support: