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EMD-45979
Cryo-EM filament structure in FTLD-synuclein
EMD-45979
Helical reconstruction3.2 Å
Deposition: 30/07/2024Map released: 14/08/2024
Last modified: 03/09/2025
Sample Organism:
Homo sapiens
Sample: Alpha-synuclein filaments extracted from the human brain with multiple system atrophy
Fitted models: 9cx6
Deposition Authors: Yang Y
,
Scheres HWS,
Goedert M
Sample: Alpha-synuclein filaments extracted from the human brain with multiple system atrophy
Fitted models: 9cx6
Deposition Authors: Yang Y
,
Scheres HWS,
Goedert M
Identical Seeding Characteristics and Cryo-EM Filament Structures in FTLD-Synuclein and Typical Multiple System Atrophy.
Cullinane PW ,
Yang Y ,
Chelban V,
Goh YY,
Ebanks K,
Curless T,
Wrigley S,
de Pablo-Fernandez E,
Holton J,
Peak-Chew S,
Franco C ,
Woerman AL,
Houlden H,
Warner TT,
Scheres SHW,
Goedert M,
Jaunmuktane Z
(2025) Neuropathol Appl Neurobiol , 51 , e70013 - e70013
,
Yang Y ,
Chelban V,
Goh YY,
Ebanks K,
Curless T,
Wrigley S,
de Pablo-Fernandez E,
Holton J,
Peak-Chew S,
Franco C ,
Woerman AL,
Houlden H,
Warner TT,
Scheres SHW,
Goedert M,
Jaunmuktane Z
(2025) Neuropathol Appl Neurobiol , 51 , e70013 - e70013
Grant Support:
- Medical Research Council (MRC, United Kingdom): MC_U105184291 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): MC_UP_A025_1013 (United Kingdom)