EMD-45892

Single-particle
2.4 Å
EMD-45892
3D View Gallery
Deposition: 23/07/2024
Map released: 23/04/2025
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-45892

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9csd summary report (pdf.gz) Map-9csd FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

The Ectodomains of SPRING and S1P with the inhibitor PF-429242

EMD-45892

Single-particle
2.4 Å
EMD-45892
3D View Gallery
Deposition: 23/07/2024
Map released: 23/04/2025
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Complex of the ectodomains of S1P and SPRING in the presence of the small molecule PF-429242
Fitted models: 9csd

Deposition Authors: Kober DL
Structural basis for substrate selectivity by site-one protease revealed by studies with a small-molecule inhibitor.
Bullington AV , Micallo I , Bajaj B , Kumar P , Schlamowitz N , Silva A , Hendrix S , Zelcer N , Kober DL
(2025) PNAS , 122 , e2426931122 - e2426931122
PUBMED: 40299693
DOI: doi:10.1073/pnas.2426931122
ISSN: 1091-6490
ASTM: PNASA6