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EMD-45739
CryoEM Strucuture of TcdB in complex with De Novo Minibinder fzd48
EMD-45739
Single-particle4.61 Å
Deposition: 12/07/2024Map released: 21/05/2025
Last modified: 08/10/2025
Sample Organism:
Escherichia coli,
synthetic construct,
Clostridioides difficile
Sample: tcdB with de novo minibinder fzd48
Fitted models: 9cm5
Deposition Authors: Weidle C, Carr KD
,
Borst AJ
Sample: tcdB with de novo minibinder fzd48
Fitted models: 9cm5
Deposition Authors: Weidle C, Carr KD
,
Borst AJ
De novo design of potent inhibitors of clostridial family toxins.
Ragotte RJ ,
Liang H ,
Tam J,
Miletic S,
Berman JM ,
Palou R ,
Weidle C,
Li Z,
Glogl M ,
Beilhartz GL ,
Carr KD ,
Borst AJ ,
Coventry B,
Wang X,
Rubinstein JL ,
Tyers M,
Schramek D,
Melnyk RA ,
Baker D
(2025) PNAS , 122 , e2509329122 - e2509329122
,
Liang H ,
Tam J,
Miletic S,
Berman JM ,
Palou R ,
Weidle C,
Li Z,
Glogl M ,
Beilhartz GL ,
Carr KD ,
Borst AJ ,
Coventry B,
Wang X,
Rubinstein JL ,
Tyers M,
Schramek D,
Melnyk RA ,
Baker D
(2025) PNAS , 122 , e2509329122 - e2509329122
Grant Support:
- Howard Hughes Medical Institute (HHMI): (United States)