EMD-45609

Single-particle
3.96 Å
EMD-45609
3D View Gallery
Deposition: 02/07/2024
Map released: 03/09/2025
Last modified: 03/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-45609

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9ci3 summary report (pdf.gz) Map-9ci3 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of the LRRK2/14-3-3 complex

EMD-45609

Single-particle
3.96 Å
EMD-45609
3D View Gallery
Deposition: 02/07/2024
Map released: 03/09/2025
Last modified: 03/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Complex of LRRK2 monomer with 14-3-3 dimer
Fitted models: 9ci3

Deposition Authors: Martinez Fiesco JA, Zhang P
14-3-3 binding maintains the Parkinson's associated kinase LRRK2 in an inactive state.
Martinez Fiesco JA, Beilina A, Alvarez de la Cruz A , Li N , Metcalfe RD , Cookson MR , Zhang P
(2025) Nat Commun , 16 , 7226 - 7226
PUBMED: 40764514
DOI: doi:10.1038/s41467-025-62337-1
ISSN: 2041-1723