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EMD-45587

Single-particle
2.7 Å
EMD-45587
3D View Gallery
Deposition: 01/07/2024
Map released: 12/03/2025
Last modified: 23/04/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-45587
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9cgv summary report (pdf.gz) Map and 9cgv FULL report (pdf.gz)
EMICSS annotations (xml)

SARS-CoV-2 nsp12 NiRAN domain bound to a covalent inhibitor SW090466-1

EMD-45587

Single-particle
2.7 Å
EMD-45587
3D View Gallery
Deposition: 01/07/2024
Map released: 12/03/2025
Last modified: 23/04/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Severe acute respiratory syndrome coronavirus 2, synthetic construct
Sample: SARS-CoV-2 nsp12 NiRAN domain bound to a covalent inhibitor SW090466-1
Fitted models: 9cgv

Deposition Authors: Osinski A, Hernandez G, Tagliabracci VS
Covalent inhibition of the SARS-CoV-2 NiRAN domain via an active-site cysteine.
Hernandez G, Osinski A, Majumdar A , Eitson JL, Antczak M, Pawlowski K, Niederstrasser H, Servage KA, Posner B, Schoggins JW, Ready JM, Tagliabracci VS
(2025) J Biol Chem , 301 , 108378 - 108378
PUBMED: 40049411
DOI: doi:10.1016/j.jbc.2025.108378
ISSN: 1083-351X
ASTM: JBCHA3