EMD-45587

Single-particle
2.7 Å
EMD-45587
3D View Gallery
Deposition: 01/07/2024
Map released: 12/03/2025
Last modified: 23/04/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-45587

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9cgv summary report (pdf.gz) Map-9cgv FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

SARS-CoV-2 nsp12 NiRAN domain bound to a covalent inhibitor SW090466-1

EMD-45587

Single-particle
2.7 Å
EMD-45587
3D View Gallery
Deposition: 01/07/2024
Map released: 12/03/2025
Last modified: 23/04/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Severe acute respiratory syndrome coronavirus 2, synthetic construct
Sample: SARS-CoV-2 nsp12 NiRAN domain bound to a covalent inhibitor SW090466-1
Fitted models: 9cgv

Deposition Authors: Osinski A, Hernandez G, Tagliabracci VS
Covalent inhibition of the SARS-CoV-2 NiRAN domain via an active-site cysteine.
Hernandez G, Osinski A, Majumdar A , Eitson JL, Antczak M, Pawlowski K, Niederstrasser H, Servage KA, Posner B, Schoggins JW, Ready JM, Tagliabracci VS
(2025) J Biol Chem , 301 , 108378 - 108378
PUBMED: 40049411
DOI: doi:10.1016/j.jbc.2025.108378
ISSN: 1083-351X
ASTM: JBCHA3