Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-45457

Single-particle
3.46 Å
EMD-45457
3D View Gallery
Deposition: 23/06/2024
Map released: 02/07/2025
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-45457
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9cct summary report (pdf.gz) Map and 9cct FULL report (pdf.gz)
EMICSS annotations (xml)

CryoEM Structure of Escherichia coli FimCH in complex with B7 Fab

EMD-45457

Single-particle
3.46 Å
EMD-45457
3D View Gallery
Deposition: 23/06/2024
Map released: 02/07/2025
Last modified: 02/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Escherichia coli, Escherichia coli UTI89
Sample: Complex of FimCH with B7 Fab
Fitted models: 9cct

Deposition Authors: Lopatto EDB , Hultgren SJ
Monoclonal antibodies targeting the FimH adhesin protect against uropathogenic E. coli UTI.
Lopatto EDB , Santiago-Borges JM , Sanick DA , Malladi SK , Azimzadeh PN , Timm MW , Fox IF, Schmitz AJ , Turner JS , Sayed Ahmed SM, Ortinau L , Gualberto NC , Pinkner JS , Dodson KW, Ellebedy AH , Kau AL , Hultgren SJ
(2025) Sci Adv , 11 , eadw0698 - eadw0698
PUBMED: 40540557
DOI: doi:10.1126/sciadv.adw0698
ISSN: 2375-2548