EMD-45456
CryoEM Structure of Escherichia coli FimCH in complex with 2H04 Fab
EMD-45456
Single-particle3.17 Å
Deposition: 23/06/2024Map released: 02/07/2025
Last modified: 02/07/2025
Sample Organism:
Mus musculus,
Escherichia coli,
Escherichia coli UTI89
Sample: Complex of FimCH with 2H04 Fab
Fitted models: 9ccs
Deposition Authors: Lopatto EDB
,
Hultgren SJ
Sample: Complex of FimCH with 2H04 Fab
Fitted models: 9ccs
Deposition Authors: Lopatto EDB
,
Hultgren SJ
Monoclonal antibodies targeting the FimH adhesin protect against uropathogenic E. coli UTI.
Lopatto EDB ,
Santiago-Borges JM ,
Sanick DA ,
Malladi SK ,
Azimzadeh PN ,
Timm MW ,
Fox IF,
Schmitz AJ ,
Turner JS ,
Sayed Ahmed SM,
Ortinau L ,
Gualberto NC ,
Pinkner JS ,
Dodson KW,
Ellebedy AH ,
Kau AL ,
Hultgren SJ
(2025) Sci Adv , 11 , eadw0698 - eadw0698
,
Santiago-Borges JM ,
Sanick DA ,
Malladi SK ,
Azimzadeh PN ,
Timm MW ,
Fox IF,
Schmitz AJ ,
Turner JS ,
Sayed Ahmed SM,
Ortinau L ,
Gualberto NC ,
Pinkner JS ,
Dodson KW,
Ellebedy AH ,
Kau AL ,
Hultgren SJ
(2025) Sci Adv , 11 , eadw0698 - eadw0698
Grant Support:
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): R01AI029549 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): R01AI048689 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): U19AI157797 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): R01AI165915 (United States)