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EMD-4542
CryoEM structure of a beta3K279T GABA(A)R homomer in complex with histamine and megabody Mb25
EMD-4542
Single-particle2.49 Å
Deposition: 09/01/2019Map released: 04/08/2021
Last modified: 09/10/2024
Sample Organism:
Homo sapiens,
Lama glama
Sample: Homomeric truncated (M3-M4 loop) GABAAR b3K279T receptor in complex with histamine and megabody Mb25
Fitted models: 6qfa
Deposition Authors: Uchanski T
,
Masiulis S
Sample: Homomeric truncated (M3-M4 loop) GABAAR b3K279T receptor in complex with histamine and megabody Mb25
Fitted models: 6qfa
Deposition Authors: Uchanski T
,
Masiulis S
Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM.
Uchanski T ,
Masiulis S,
Fischer B ,
Kalichuk V ,
Lopez-Sanchez U ,
Zarkadas E ,
Weckener M ,
Sente A ,
Ward P,
Wohlkonig A ,
Zogg T ,
Remaut H ,
Naismith JH,
Nury H,
Vranken W ,
Aricescu AR ,
Pardon E ,
Steyaert J
(2021) Nat Methods , 18 , 60 - 68
,
Masiulis S,
Fischer B ,
Kalichuk V ,
Lopez-Sanchez U ,
Zarkadas E ,
Weckener M ,
Sente A ,
Ward P,
Wohlkonig A ,
Zogg T ,
Remaut H ,
Naismith JH,
Nury H,
Vranken W ,
Aricescu AR ,
Pardon E ,
Steyaert J
(2021) Nat Methods , 18 , 60 - 68
Grant Support:
- Medical Research Council (United Kingdom): MC_UP_1201/15 (United Kingdom)
- Medical Research Council (United Kingdom): L009609/1 (United Kingdom)
- European Union: 731005 (Belgium)
- Grenoble Instruct-ERIC Center: (Belgium)
- Research Foundation - Flanders: (Belgium)