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EMD-45360
Cryo-EM structure of TAP binding protein related (TAPBPR) in complex with HLA-A*02:01 bound to a suboptimal peptide.
EMD-45360
Single-particle3.0 Å
Deposition: 13/06/2024Map released: 22/01/2025
Last modified: 29/01/2025
Sample Organism:
Homo sapiens
Sample: Complex of peptide loaded HLA-A*02:01/beta-2-microglobulin in complex with human TAPBPR.
Fitted models: 9c96
Deposition Authors: Pumroy RP, Mallik L, Sun Y, Moiseenkova-Bell YV, Sgourakis NG
Sample: Complex of peptide loaded HLA-A*02:01/beta-2-microglobulin in complex with human TAPBPR.
Fitted models: 9c96
Deposition Authors: Pumroy RP, Mallik L, Sun Y, Moiseenkova-Bell YV, Sgourakis NG
CryoEM structure of an MHC-I/TAPBPR peptide-bound intermediate reveals the mechanism of antigen proofreading.
Sun Y,
Pumroy RA ,
Mallik L,
Chaudhuri A,
Wang C,
Hwang D ,
Danon JN ,
Dasteh Goli K,
Moiseenkova-Bell VY ,
Sgourakis NG
(2025) PNAS , 122 , e2416992122 - e2416992122
,
Mallik L,
Chaudhuri A,
Wang C,
Hwang D ,
Danon JN ,
Dasteh Goli K,
Moiseenkova-Bell VY ,
Sgourakis NG
(2025) PNAS , 122 , e2416992122 - e2416992122
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R01Al143997 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R35GM125034 (United States)
- Cancer Research UK: CGCATF-2021/100002 (United Kingdom)
- National Institutes of Health/National Cancer Institute (NIH/NCI): CA278687-01 (United States)
- The Mark Foundation: (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R35GM144120 (United States)