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EMD-45301
mouse Seipin/Adig complex
EMD-45301
Single-particle2.98 Å
Deposition: 12/06/2024Map released: 27/08/2025
Last modified: 19/11/2025
Sample Organism:
Mus musculus
Sample: Seipin/Adig complex
Fitted models: 9c8d
Deposition Authors: Li C
,
Han Y ,
Wynn RM ,
Chen Z,
Scherer PE
Sample: Seipin/Adig complex
Fitted models: 9c8d
Deposition Authors: Li C
,
Han Y ,
Wynn RM ,
Chen Z,
Scherer PE
Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex.
Li C ,
Sun XN ,
Funcke JB ,
Vanharanta L ,
Prasanna X ,
Gov K ,
Li Y ,
Virostek M ,
Joung C ,
Joffin N,
Kanerva K ,
Szkalisity A ,
Kulig W ,
Straub L ,
Chen S,
Velasco J,
Cobb A,
La Padula D ,
Wang MY,
Onodera T ,
Voros C ,
Kim DS ,
Kim M,
Varlamov O ,
Li Y ,
Liu C ,
Nawrocki AR ,
Zhao S ,
Oh DY ,
Wang ZV ,
Gordillo R ,
Goodman JM,
Wynn RM ,
Henne WM,
Vattulainen I ,
Han Y ,
Ikonen E ,
Scherer PE
(2025) Science , 390 , eadr9755 - eadr9755
,
Sun XN ,
Funcke JB ,
Vanharanta L ,
Prasanna X ,
Gov K ,
Li Y ,
Virostek M ,
Joung C ,
Joffin N,
Kanerva K ,
Szkalisity A ,
Kulig W ,
Straub L ,
Chen S,
Velasco J,
Cobb A,
La Padula D ,
Wang MY,
Onodera T ,
Voros C ,
Kim DS ,
Kim M,
Varlamov O ,
Li Y ,
Liu C ,
Nawrocki AR ,
Zhao S ,
Oh DY ,
Wang ZV ,
Gordillo R ,
Goodman JM,
Wynn RM ,
Henne WM,
Vattulainen I ,
Han Y ,
Ikonen E ,
Scherer PE
(2025) Science , 390 , eadr9755 - eadr9755
Grant Support:
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): RC2-DK118620 (United States)
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): R01- DK55758 (United States)
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): R01-DK099110 (United States)
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): R01-DK127274 (United States)
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): R01-DK131537 (United States)