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EMD-45242
mGluR3 in the presence of the antagonist LY 341495 and positive allosteric modulator VU6023326 class 2
EMD-45242
Single-particle3.8 Å
Deposition: 07/06/2024Map released: 31/07/2024
Last modified: 14/08/2024
Sample Organism:
Rattus norvegicus
Sample: Metabotropic Glutamate Receptor 3 dimer
Deposition Authors: Strauss A
,
Levitz J
Sample: Metabotropic Glutamate Receptor 3 dimer
Deposition Authors: Strauss A
,
Levitz J
Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization.
Strauss A ,
Gonzalez-Hernandez AJ ,
Lee J ,
Abreu N,
Selvakumar P,
Salas-Estrada L ,
Kristt M ,
Arefin A ,
Huynh K,
Marx DC,
Gilliland K,
Melancon BJ,
Filizola M ,
Meyerson J,
Levitz J
(2024) Nat Commun , 15 , 6498 - 6498
,
Gonzalez-Hernandez AJ ,
Lee J ,
Abreu N,
Selvakumar P,
Salas-Estrada L ,
Kristt M ,
Arefin A ,
Huynh K,
Marx DC,
Gilliland K,
Melancon BJ,
Filizola M ,
Meyerson J,
Levitz J
(2024) Nat Commun , 15 , 6498 - 6498
Grant Support:
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): 1F31NS129320 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): F32GM148001 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R01NS129904 (United States)