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EMD-45186
Cryo-EM structure of a FAM72A-MKLN1-RANBP9-TWA1 complex
EMD-45186
Single-particle5.8 Å
Deposition: 04/06/2024Map released: 11/09/2024
Last modified: 11/09/2024
Sample Organism:
Homo sapiens
Sample: Cryo-EM structure a FAM72A-MKLN1-RANBP9-TWA1 subcomplex from focused refinement of CTLH-MKLN1-FAM72A in complex with UNG2
Deposition Authors: Chana CK, Keszei AFA, Sicheri F
Sample: Cryo-EM structure a FAM72A-MKLN1-RANBP9-TWA1 subcomplex from focused refinement of CTLH-MKLN1-FAM72A in complex with UNG2
Deposition Authors: Chana CK, Keszei AFA, Sicheri F
FAM72A degrades UNG2 through the GID/CTLH complex to promote mutagenic repair during antibody maturation.
Barbulescu P,
Chana CK,
Wong MK,
Ben Makhlouf I ,
Bruce JP,
Feng Y,
Keszei AFA,
Wong C,
Mohamad-Ramshan R,
McGary LC,
Kashem MA,
Ceccarelli DF ,
Orlicky S,
Fang Y,
Kuang H,
Mazhab-Jafari M,
Pezo RC,
Bhagwat AS ,
Pugh TJ ,
Gingras AC ,
Sicheri F ,
Martin A
(2024) Nat Commun , 15 , 7541 - 7541
,
Bruce JP,
Feng Y,
Keszei AFA,
Wong C,
Mohamad-Ramshan R,
McGary LC,
Kashem MA,
Ceccarelli DF ,
Orlicky S,
Fang Y,
Kuang H,
Mazhab-Jafari M,
Pezo RC,
Bhagwat AS ,
Pugh TJ ,
Gingras AC ,
Sicheri F ,
Martin A
(2024) Nat Commun , 15 , 7541 - 7541
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