EMD-44979

Single-particle
2.5 Å
EMD-44979
3D View Gallery
Deposition: 21/05/2024
Map released: 04/09/2024
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-44979

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9bwt summary report (pdf.gz) Map-9bwt FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

human sodium chloride cotransporter NCC S344E in the phosphorylation state and in complex with hydrochlorothiazide

EMD-44979

Single-particle
2.5 Å
EMD-44979
3D View Gallery
Deposition: 21/05/2024
Map released: 04/09/2024
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Phosphorylated SLC12A3 transporter in complex with hydrochlorothiazide
Fitted models: 9bwt

Deposition Authors: Cao EH, Zhao YX
Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases.
Zhao Y, Schubert H, Blakely A, Forbush B , Smith MD , Rinehart J , Cao E
(2024) Nat Commun , 15 , 7006 - 7006
PUBMED: 39143061
DOI: doi:10.1038/s41467-024-51381-y
ISSN: 2041-1723