EMD-44962
Tetrameric Complex of full-length HIV-1 integrase protein bound to the integrase binding domain of LEDGF/p75
EMD-44962
Single-particle4.1 Å
Deposition: 21/05/2024Map released: 25/06/2025
Last modified: 05/11/2025
Sample Organism:
HIV type 1,
Homo sapiens,
HIV-1 06TG.HT008
Sample: Full-length tetrameric HIV-1 integrase bound to LEDGF IBD
Fitted models: 9bw9
Deposition Authors: Jing T
,
Shan Z ,
Lyumkis D ,
Biswas A
Sample: Full-length tetrameric HIV-1 integrase bound to LEDGF IBD
Fitted models: 9bw9
Deposition Authors: Jing T
,
Shan Z ,
Lyumkis D ,
Biswas A
Oligomeric HIV-1 integrase structures reveal functional plasticity for intasome assembly and RNA binding.
Jing T ,
Shan Z ,
Dinh T ,
Biswas A ,
Jang S,
Greenwood J,
Li M ,
Zhang Z,
Gray G,
Shin HJ,
Zhou B,
Passos D,
Strutzenberg TS,
Aiyer S ,
Andrade L ,
Zhang Y ,
Li Z,
Craigie R,
Engelman AN ,
Kvaratskhelia M ,
Lyumkis D
(2025) Nat Commun , 16 , 9430 - 9430
,
Shan Z ,
Dinh T ,
Biswas A ,
Jang S,
Greenwood J,
Li M ,
Zhang Z,
Gray G,
Shin HJ,
Zhou B,
Passos D,
Strutzenberg TS,
Aiyer S ,
Andrade L ,
Zhang Y ,
Li Z,
Craigie R,
Engelman AN ,
Kvaratskhelia M ,
Lyumkis D
(2025) Nat Commun , 16 , 9430 - 9430
Grant Support:
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): AI136680 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): AI146017 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): AI170855 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): AI039394 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): AI170791 (United States)