EMD-44946

Single-particle
3.0 Å
EMD-44946
3D View Gallery
Deposition: 20/05/2024
Map released: 21/05/2025
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-44946
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
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EMICSS annotations (xml)

5HT2AR-miniGq heterotrimer in complex with a novel agonist obtained from large scale docking, local refinement of heterotrimer

EMD-44946

Single-particle
3.0 Å
EMD-44946
3D View Gallery
Deposition: 20/05/2024
Map released: 21/05/2025
Last modified: 21/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Active state complex of 5HT2AR with mini-Gq heterotrimer stabilized by scFv16

Deposition Authors: Gumpper RH, Wang L , Kapolka N , Skiniotis G , Roth BL
AlphaFold2 structures guide prospective ligand discovery.
Lyu J , Kapolka N , Gumpper R, Alon A , Wang L , Jain MK , Barros-Alvarez X , Sakamoto K , Kim Y, DiBerto J , Kim K , Glenn IS , Tummino TA , Huang S, Irwin JJ , Tarkhanova OO , Moroz Y , Skiniotis G , Kruse AC , Shoichet BK , Roth BL
(2024) Science , 384 , eadn6354 - eadn6354
PUBMED: 38753765
DOI: doi:10.1126/science.adn6354
ISSN: 1095-9203
ASTM: SCIEAS