Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-44946
5HT2AR-miniGq heterotrimer in complex with a novel agonist obtained from large scale docking, local refinement of heterotrimer
EMD-44946
Single-particle3.0 Å
Deposition: 20/05/2024Map released: 21/05/2025
Last modified: 21/05/2025
Sample Organism:
Homo sapiens
Sample: Active state complex of 5HT2AR with mini-Gq heterotrimer stabilized by scFv16
Deposition Authors: Gumpper RH, Wang L
,
Kapolka N ,
Skiniotis G ,
Roth BL
Sample: Active state complex of 5HT2AR with mini-Gq heterotrimer stabilized by scFv16
Deposition Authors: Gumpper RH, Wang L
,
Kapolka N ,
Skiniotis G ,
Roth BL
AlphaFold2 structures guide prospective ligand discovery.
Lyu J ,
Kapolka N ,
Gumpper R,
Alon A ,
Wang L ,
Jain MK ,
Barros-Alvarez X ,
Sakamoto K ,
Kim Y,
DiBerto J ,
Kim K ,
Glenn IS ,
Tummino TA ,
Huang S,
Irwin JJ ,
Tarkhanova OO ,
Moroz Y ,
Skiniotis G ,
Kruse AC ,
Shoichet BK ,
Roth BL
(2024) Science , 384 , eadn6354 - eadn6354
,
Kapolka N ,
Gumpper R,
Alon A ,
Wang L ,
Jain MK ,
Barros-Alvarez X ,
Sakamoto K ,
Kim Y,
DiBerto J ,
Kim K ,
Glenn IS ,
Tummino TA ,
Huang S,
Irwin JJ ,
Tarkhanova OO ,
Moroz Y ,
Skiniotis G ,
Kruse AC ,
Shoichet BK ,
Roth BL
(2024) Science , 384 , eadn6354 - eadn6354
Grant Support:
- Defense Advanced Research Projects Agency (DARPA): HR0011-20-2-0029 (United States)