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EMD-44866

Single-particle
2.32 Å
EMD-44866
3D View Gallery
Deposition: 13/05/2024
Map released: 17/09/2025
Last modified: 15/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-44866
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9bsb summary report (pdf.gz) Map and 9bsb FULL report (pdf.gz)
EMICSS annotations (xml)

Global reconstruction of DRD2 bound to LSD in complex with a mini-GoA and scFv16 obtained by cryo-electron microscopy (cryoEM)

EMD-44866

Single-particle
2.32 Å
EMD-44866
3D View Gallery
Deposition: 13/05/2024
Map released: 17/09/2025
Last modified: 15/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: DRD2 in complex mini-GoA
Fitted models: 9bsb

Deposition Authors: Kim K, Gumpper RH, Fay JF, Roth BL
The polypharmacology of psychedelics reveals multiple targets for potential therapeutics.
Jain MK, Gumpper RH, Slocum ST, Schmitz GP, Madsen JS , Tummino TA, Suomivuori CM, Huang XP, Shub L, DiBerto JF, Kim K, DeLeon C, Krumm BE, Fay JF, Keiser M , Hauser AS, Dror RO , Shoichet B, Gloriam DE , Nichols DE, Roth BL
(2025) Neuron , 113 , 3129 - 3142.e9
PUBMED: 40683247
DOI: doi:10.1016/j.neuron.2025.06.012
ISSN: 0896-6273
ASTM: NERNET