EMD-44866

Single-particle
2.32 Å
EMD-44866
3D View Gallery
Deposition: 13/05/2024
Map released: 17/09/2025
Last modified: 15/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-44866

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9bsb summary report (pdf.gz) Map-9bsb FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Global reconstruction of DRD2 bound to LSD in complex with a mini-GoA and scFv16 obtained by cryo-electron microscopy (cryoEM)

EMD-44866

Single-particle
2.32 Å
EMD-44866
3D View Gallery
Deposition: 13/05/2024
Map released: 17/09/2025
Last modified: 15/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: DRD2 in complex mini-GoA
Fitted models: 9bsb

Deposition Authors: Kim K, Gumpper RH, Fay JF, Roth BL
The polypharmacology of psychedelics reveals multiple targets for potential therapeutics.
Jain MK, Gumpper RH, Slocum ST, Schmitz GP, Madsen JS , Tummino TA, Suomivuori CM, Huang XP, Shub L, DiBerto JF, Kim K, DeLeon C, Krumm BE, Fay JF, Keiser M , Hauser AS, Dror RO , Shoichet B, Gloriam DE , Nichols DE, Roth BL
(2025) Neuron , 113 , 3129 - 3142.e9
PUBMED: 40683247
DOI: doi:10.1016/j.neuron.2025.06.012
ISSN: 0896-6273
ASTM: NERNET