EMD-44642
Cholecystokinin 1 receptor (CCK1R) Y140A mutant, Gq chimera (mGsqi) complex
EMD-44642
Single-particle2.59 Å
Deposition: 29/04/2024Map released: 22/05/2024
Last modified: 14/08/2024
Sample Organism:
Homo sapiens
Sample: Complex of CCK1R (Y140A mutant) bound to miniGs (Gq, Gi chimera), G-beta1, G-gamma-2 and CCK8s.
Fitted models: 9bkj
Deposition Authors: Cary BP
,
Harikumar KG,
Zhao P,
Desai AJ,
Mobbs JM,
Toufaily C,
Furness SGB ,
Christopoulos A,
Belousoff MJ,
Wootten D ,
Sexton PM,
Miller LJ
Sample: Complex of CCK1R (Y140A mutant) bound to miniGs (Gq, Gi chimera), G-beta1, G-gamma-2 and CCK8s.
Fitted models: 9bkj
Deposition Authors: Cary BP
,
Harikumar KG,
Zhao P,
Desai AJ,
Mobbs JM,
Toufaily C,
Furness SGB ,
Christopoulos A,
Belousoff MJ,
Wootten D ,
Sexton PM,
Miller LJ
Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling.
Harikumar KG,
Zhao P,
Cary BP ,
Xu X ,
Desai AJ,
Dong M,
Mobbs JI,
Toufaily C,
Furness SGB ,
Christopoulos A,
Belousoff MJ,
Wootten D ,
Sexton PM,
Miller LJ
(2024) PLoS Biol , 22 , e3002673 - e3002673
,
Xu X ,
Desai AJ,
Dong M,
Mobbs JI,
Toufaily C,
Furness SGB ,
Christopoulos A,
Belousoff MJ,
Wootten D ,
Sexton PM,
Miller LJ
(2024) PLoS Biol , 22 , e3002673 - e3002673
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM141003 (United States)
- National Health and Medical Research Council (NHMRC, Australia): 1154434 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 1155302 (Australia)
- Australian Research Council (ARC): FT180100543 (Australia)