EMD-44635
Inactive mu opioid receptor bound to Nb6, naloxone and NAM
EMD-44635
Single-particle3.26 Å
Deposition: 25/04/2024Map released: 17/07/2024
Last modified: 21/05/2025
Sample Organism:
Mus musculus,
Lama glama
Sample: mu-type opioid receptor with kappa-type opioid receptor ICL3 in complex with Nb6, naloxone and a negative allosteric modulator
Fitted models: 9bjk
Deposition Authors: O'Brien ES
,
Wang H,
Kaavya Krishna K,
Zhang C,
Kobilka BK
Sample: mu-type opioid receptor with kappa-type opioid receptor ICL3 in complex with Nb6, naloxone and a negative allosteric modulator
Fitted models: 9bjk
Deposition Authors: O'Brien ES
,
Wang H,
Kaavya Krishna K,
Zhang C,
Kobilka BK
A mu-opioid receptor modulator that works cooperatively with naloxone.
O'Brien ES ,
Rangari VA ,
El Daibani A,
Eans SO,
Hammond HR,
White E,
Wang H,
Shiimura Y,
Krishna Kumar K ,
Jiang Q,
Appourchaux K ,
Huang W,
Zhang C,
Kennedy BJ ,
Mathiesen JM,
Che T ,
McLaughlin JP ,
Majumdar S ,
Kobilka BK
(2024) Nature , 631 , 686 - 693
,
Rangari VA ,
El Daibani A,
Eans SO,
Hammond HR,
White E,
Wang H,
Shiimura Y,
Krishna Kumar K ,
Jiang Q,
Appourchaux K ,
Huang W,
Zhang C,
Kennedy BJ ,
Mathiesen JM,
Che T ,
McLaughlin JP ,
Majumdar S ,
Kobilka BK
(2024) Nature , 631 , 686 - 693
Grant Support:
- Chan Zuckerberg Initiative: (United States)