EMD-44633

Single-particle
2.83 Å
EMD-44633
3D View Gallery
Deposition: 25/04/2024
Map released: 21/01/2026
Last modified: 21/01/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-44633
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9bji summary report (pdf.gz) Map and 9bji FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of apo NVL

EMD-44633

Single-particle
2.83 Å
EMD-44633
3D View Gallery
Deposition: 25/04/2024
Map released: 21/01/2026
Last modified: 21/01/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Escherichia coli BL21(DE3)
Sample: apo NVL
Fitted models: 9bji

Deposition Authors: Cruz VE, Erzberger JP

Dibenzothiazepinones are bioavailable inhibitors of NVL and cause p53-dependent apoptosis in cancer by blocking 60S ribosome assembly
Guo HH, Tao Y, Cruz VE, Fang M, Khivansara V, Xie S, Leach A, Rivera-Cancel G, Barrows N, Williams N, Aurora A, Erzberger JP, De Brabander JK, Nijhawan D
To Be Published
Grant Support: