EMD-44595
Structure of VRC44.01 Fab in complex with 3BNC117-purified C1080.c3 RnS SOSIP.664 HIV-1 Env trimer
EMD-44595
Single-particle2.83 Å
Deposition: 23/04/2024Map released: 13/11/2024
Last modified: 01/01/2025
Sample Organism:
Homo sapiens,
Human immunodeficiency virus 1
Sample: VRC44 and 3BNC117 Fabs with Repaired C1080 Env trimer
Fitted models: 9bio
Deposition Authors: Gorman J, Kwong PD
Sample: VRC44 and 3BNC117 Fabs with Repaired C1080 Env trimer
Fitted models: 9bio
Deposition Authors: Gorman J, Kwong PD
A multidonor class of highly glycan-dependent HIV-1 gp120-gp41 interface-targeting broadly neutralizing antibodies.
Cale EM,
Shen CH,
Olia AS,
Radakovich NA,
Rawi R,
Yang Y,
Ambrozak DR,
Bennici AK,
Chuang GY,
Crooks ED,
Driscoll JI,
Lin BC,
Louder MK,
Madden PJ ,
Messina MA,
Osawa K,
Stewart-Jones GBE,
Verardi R,
Vrakas Z,
Xie D ,
Zhang B,
Binley JM,
Connors M,
Koup RA,
Pierson TC ,
Doria-Rose NA,
Kwong PD ,
Mascola JR,
Gorman J
(2024) Cell Rep , 43 , 115010 - 115010
,
Messina MA,
Osawa K,
Stewart-Jones GBE,
Verardi R,
Vrakas Z,
Xie D ,
Zhang B,
Binley JM,
Connors M,
Koup RA,
Pierson TC ,
Doria-Rose NA,
Kwong PD ,
Mascola JR,
Gorman J
(2024) Cell Rep , 43 , 115010 - 115010
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM103310 (United States)
- Simons Foundation: SF349247 (United States)