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EMD-44539
Cryo-EM structure of human monoclonal antibody C74 targeting PFD1235w (CIDRa1.6) PfEMP1
EMD-44539
Single-particle3.1 Å
Deposition: 19/04/2024Map released: 02/10/2024
Last modified: 04/06/2025
Sample Organism:
Plasmodium falciparum 3D7,
Homo sapiens
Sample: Complex of human monoclonal C74 with PfEMP1 PFD1235w N-terminal domain complex
Fitted models: 9bhb
Deposition Authors: Raghavan SSR
,
Ward AB
Sample: Complex of human monoclonal C74 with PfEMP1 PFD1235w N-terminal domain complex
Fitted models: 9bhb
Deposition Authors: Raghavan SSR
,
Ward AB
Broadly inhibitory antibodies to severe malaria virulence proteins.
Reyes RA ,
Raghavan SSR ,
Hurlburt NK ,
Introini V ,
Bol S ,
Kana IH ,
Jensen RW,
Martinez-Scholze E,
Gestal-Mato M ,
Lopez-Gutierrez B ,
Sanz S ,
Bancells C,
Fernandez-Quintero ML ,
Loeffler JR,
Ferguson JA,
Lee WH ,
Martin GM,
Theander TG ,
Lusingu JPA,
Minja DTR,
Ssewanyana I,
Feeney ME ,
Greenhouse B,
Ward AB ,
Bernabeu M ,
Pancera M ,
Turner L ,
Bunnik EM ,
Lavstsen T
(2024) Nature , 636 , 182 - 189
,
Raghavan SSR ,
Hurlburt NK ,
Introini V ,
Bol S ,
Kana IH ,
Jensen RW,
Martinez-Scholze E,
Gestal-Mato M ,
Lopez-Gutierrez B ,
Sanz S ,
Bancells C,
Fernandez-Quintero ML ,
Loeffler JR,
Ferguson JA,
Lee WH ,
Martin GM,
Theander TG ,
Lusingu JPA,
Minja DTR,
Ssewanyana I,
Feeney ME ,
Greenhouse B,
Ward AB ,
Bernabeu M ,
Pancera M ,
Turner L ,
Bunnik EM ,
Lavstsen T
(2024) Nature , 636 , 182 - 189
Grant Support:
- Bill & Melinda Gates Foundation: (United States)
- Lundbeckfonden: (Denmark)