Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-44536

Single-particle
3.6 Å
EMD-44536
3D View Gallery
Deposition: 19/04/2024
Map released: 01/05/2024
Last modified: 25/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-44536
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9bh8 summary report (pdf.gz) Map and 9bh8 FULL report (pdf.gz)
EMICSS annotations (xml)

Human DNA polymerase theta helicase domain dimer bound to DNA in the microhomology searching conformation

EMD-44536

Single-particle
3.6 Å
EMD-44536
3D View Gallery
Deposition: 19/04/2024
Map released: 01/05/2024
Last modified: 25/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: Human DNA polymerase theta helicase domain bound to stem-loop DNA with microhomology in the 3' overhang
Fitted models: 9bh8

Deposition Authors: Zerio CJ, Lander GC
Human polymerase theta helicase positions DNA microhomologies for double-strand break repair.
Zerio CJ, Bai Y, Sosa-Alvarado BA, Guzi T, Lander GC
(2025) Nat Struct Mol Biol , 32 , 1061 - 1068
PUBMED: 40021738
DOI: doi:10.1038/s41594-025-01514-8
ISSN: 1545-9985