EMD-44441
Cryo-EM structure of the S. cerevisiae ORC-Cdc6-Mcm2-7-DNA complex with a fully closed Mcm2-Mcm5 DNA entry gate
EMD-44441
Single-particle6.1 Å
Deposition: 10/04/2024Map released: 01/01/2025
Last modified: 15/01/2025
Sample Organism:
Saccharomyces cerevisiae,
synthetic construct
Sample: ORC-Cdc6-Mcm2-7-dsDNA
Fitted models: 9bcx
Deposition Authors: Yuan Z
,
Bai L,
Li H ,
Speck C
Sample: ORC-Cdc6-Mcm2-7-dsDNA
Fitted models: 9bcx
Deposition Authors: Yuan Z
,
Bai L,
Li H ,
Speck C
MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis.
Faull SV ,
Barbon M ,
Mossler A ,
Yuan Z ,
Bai L,
Reuter LM ,
Riera A,
Winkler C,
Magdalou I,
Peach M ,
Li H ,
Speck C
(2025) Nat Commun , 16 , 14 - 14
,
Barbon M ,
Mossler A ,
Yuan Z ,
Bai L,
Reuter LM ,
Riera A,
Winkler C,
Magdalou I,
Peach M ,
Li H ,
Speck C
(2025) Nat Commun , 16 , 14 - 14
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM110387 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM131754 (United States)
- Biotechnology and Biological Sciences Research Council (BBSRC): BB/S001387/1 (United Kingdom)
- Biotechnology and Biological Sciences Research Council (BBSRC): BB/N000323/1 (United Kingdom)
- Wellcome Trust: 107903/Z/15/Z (United Kingdom)