EMD-44386

Single-particle
2.6 Å
EMD-44386
3D View Gallery
Deposition: 02/04/2024
Map released: 05/02/2025
Last modified: 22/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-44386

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9b9j summary report (pdf.gz) Map-9b9j FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Integrin alpha-5 beta-1 in complex with BIIG2 Fab

EMD-44386

Single-particle
2.6 Å
EMD-44386
3D View Gallery
Deposition: 02/04/2024
Map released: 05/02/2025
Last modified: 22/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Rattus norvegicus
Sample: Protein complex of integrin alpha-5 beta-1 with BIIG2 Fab
Fitted models: 9b9j

Deposition Authors: Nguyen A, Azumaya CM, Campbell MG
Shared ligand-blocking mechanism but distinct conformational modulation by alpha 5-targeting antibodies BIIG2 and MINT1526A.
Nguyen A, Heim JB, Cordara G, Chan MC, Johannesen H, Charlesworth C, Li M, Azumaya CM, Madden B, Krengel U, Meves A, Campbell MG
(2025) bioRxiv
PUBMED: 39829743
DOI: doi:10.1101/2025.01.08.631572
ISSN: 2692-8205