EMD-44253
Human asparagine synthetase Arg-142 to Ile-142 (R142I) variant
EMD-44253
Single-particle3.35 Å
Deposition: 25/03/2024Map released: 08/01/2025
Last modified: 05/02/2025
Sample Organism:
Homo sapiens
Sample: human asparagine synthetase dimer form
Fitted models: 9b6c
Deposition Authors: Coricello A
,
Nardone A,
Lupia A ,
Gratteri C ,
Vos M,
Chaptal V ,
Alcaro S ,
Zhu W ,
Takagi Y ,
Richards N
Sample: human asparagine synthetase dimer form
Fitted models: 9b6c
Deposition Authors: Coricello A
,
Nardone A,
Lupia A ,
Gratteri C ,
Vos M,
Chaptal V ,
Alcaro S ,
Zhu W ,
Takagi Y ,
Richards N
3D variability analysis reveals a hidden conformational change controlling ammonia transport in human asparagine synthetase.
Coricello A ,
Nardone AJ,
Lupia A ,
Gratteri C ,
Vos M,
Chaptal V ,
Alcaro S ,
Zhu W ,
Takagi Y ,
Richards NGJ
(2024) Nat Commun , 15 , 10538 - 10538
,
Nardone AJ,
Lupia A ,
Gratteri C ,
Vos M,
Chaptal V ,
Alcaro S ,
Zhu W ,
Takagi Y ,
Richards NGJ
(2024) Nat Commun , 15 , 10538 - 10538
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R01GM111695 (United States)
- American Cancer Society: DBG-23-1038947-01-IBCD (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): S10OD028723 (United States)
- Centre National de la Recherche Scientifique (CNRS): ANR-19-CE11-0023-01 (France)
- Biotechnology and Biological Sciences Research Council (BBSRC): P/0118017/1 (United Kingdom)
- European Commission: FESR FSE 2014- 2020 (European Union)