EMD-44247

Single-particle
3.03 Å
EMD-44247
3D View Gallery
Deposition: 23/03/2024
Map released: 05/03/2025
Last modified: 16/04/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-44247
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9b65 summary report (pdf.gz) Map and 9b65 FULL report (pdf.gz)
EMICSS annotations (xml)

Biased agonist bound CB1-Gi structure

EMD-44247

Single-particle
3.03 Å
EMD-44247
3D View Gallery
Deposition: 23/03/2024
Map released: 05/03/2025
Last modified: 16/04/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: CB1-Gi complex
Fitted models: 9b65

Deposition Authors: Rangari VA , O'Brien ES , Kobilka BK , Krishna Kumar K , Majumdar S
A cryptic pocket in CB1 drives peripheral and functional selectivity.
Rangari VA , O'Brien ES , Powers AS, Slivicki RA , Bertels Z, Appourchaux K , Aydin D , Ramos-Gonzalez N , Mwirigi J , Lin L, Mangutov E, Sobecks BL, Awad-Agbaria Y , Uphade MB, Aguilar J, Peddada TN, Shiimura Y, Huang XP , Folarin-Hines J, Payne M, Kalathil A, Varga BR, Kobilka BK , Pradhan AA , Cameron MD , Kumar KK, Dror RO , Gereau 4th RW , Majumdar S
(2025) Nature , 640 , 265 - 273
PUBMED: 40044849
DOI: doi:10.1038/s41586-025-08618-7
ISSN: 1476-4687
ASTM: NATUAS