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EMD-44229
Cryo-EM structure of the LAPTH-bound PTH1R in complex with Gq
EMD-44229
Single-particle3.49 Å
Deposition: 22/03/2024Map released: 19/03/2025
Last modified: 04/06/2025
Sample Organism:
Homo sapiens,
Spodoptera frugiperda,
Mus musculus
Sample: LAPTH-PTH1R-Gq complex
Fitted models: 9b5y
Deposition Authors: Zhang X
,
Liu H,
Zhang C ,
Vilardaga J-P
Sample: LAPTH-PTH1R-Gq complex
Fitted models: 9b5y
Deposition Authors: Zhang X
,
Liu H,
Zhang C ,
Vilardaga J-P
Allosteric mechanism in the distinctive coupling of G q and G s to the parathyroid hormone type 1 receptor.
Zhang X ,
Lee JY,
Pacheco J,
Sutkeviciute I,
Anitha AK,
Liu H,
Singh S,
Ventura C,
Savransky S,
Khatri A,
Zhang C ,
Bahar I ,
Vilardaga JP
(2025) PNAS , 122 , e2426178122 - e2426178122
,
Lee JY,
Pacheco J,
Sutkeviciute I,
Anitha AK,
Liu H,
Singh S,
Ventura C,
Savransky S,
Khatri A,
Zhang C ,
Bahar I ,
Vilardaga JP
(2025) PNAS , 122 , e2426178122 - e2426178122
Grant Support:
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): R01DK116780 (United States)
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): R01DK122259 (United States)
- National Institutes of Health/National Institute of Dental and Craniofacial Research (NIH/NIDCR): R21DE032478 (United States)