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EMD-44199
Biased agonist bound CB1-Gi structure
EMD-44199
Single-particle2.86 Å
Deposition: 22/03/2024Map released: 05/03/2025
Last modified: 16/04/2025
Sample Organism:
Homo sapiens,
Mus musculus
Sample: CB1-Gi complex
Fitted models: 9b54
Deposition Authors: Rangari VA
,
O'Brien ES ,
Kobilka BK ,
Krishna Kumar K ,
Majumdar S
Sample: CB1-Gi complex
Fitted models: 9b54
Deposition Authors: Rangari VA
,
O'Brien ES ,
Kobilka BK ,
Krishna Kumar K ,
Majumdar S
A cryptic pocket in CB1 drives peripheral and functional selectivity.
Rangari VA ,
O'Brien ES ,
Powers AS,
Slivicki RA ,
Bertels Z,
Appourchaux K ,
Aydin D ,
Ramos-Gonzalez N ,
Mwirigi J ,
Lin L,
Mangutov E,
Sobecks BL,
Awad-Agbaria Y ,
Uphade MB,
Aguilar J,
Peddada TN ,
Shiimura Y,
Huang XP ,
Folarin-Hines J,
Payne M,
Kalathil A,
Varga BR,
Kobilka BK ,
Pradhan AA ,
Cameron MD ,
Kumar KK,
Dror RO ,
Gereau 4th RW ,
Majumdar S
(2025) Nature , 640 , 265 - 273
,
O'Brien ES ,
Powers AS,
Slivicki RA ,
Bertels Z,
Appourchaux K ,
Aydin D ,
Ramos-Gonzalez N ,
Mwirigi J ,
Lin L,
Mangutov E,
Sobecks BL,
Awad-Agbaria Y ,
Uphade MB,
Aguilar J,
Peddada TN ,
Shiimura Y,
Huang XP ,
Folarin-Hines J,
Payne M,
Kalathil A,
Varga BR,
Kobilka BK ,
Pradhan AA ,
Cameron MD ,
Kumar KK,
Dror RO ,
Gereau 4th RW ,
Majumdar S
(2025) Nature , 640 , 265 - 273
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