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EMD-44186

Helical reconstruction
3.5 Å
EMD-44186
3D View Gallery
Deposition: 21/03/2024
Map released: 12/03/2025
Last modified: 03/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-44186
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9b4n summary report (pdf.gz) Map and 9b4n FULL report (pdf.gz)
EMICSS annotations (xml)

Filament of Tau in complex with D-TLKIVWR, a D-peptide that disaggregates Alzheimer's Paired Helical Filaments, determined by Cryo-EM

EMD-44186

Helical reconstruction
3.5 Å
EMD-44186
3D View Gallery
Deposition: 21/03/2024
Map released: 12/03/2025
Last modified: 03/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: Tau PHF - D-TLKIVWR Complex
Fitted models: 9b4n

Deposition Authors: Hou K , Ge P , Sawaya MR , Eisenberg DS
How short peptides disassemble tau fibrils in Alzheimer's disease.
Hou K , Ge P , Sawaya MR , Lutter L, Dolinsky JL , Yang Y , Jiang YX , Boyer DR , Cheng X , Pi J , Zhang J, Lu J, Abskharon R, Yang S , Yu Z , Feigon J , Eisenberg DS
(2025) Nature , 644 , 1020 - 1027
PUBMED: 40634605
DOI: doi:10.1038/s41586-025-09244-z
ISSN: 1476-4687
ASTM: NATUAS