EMD-44124
Structure of concanavalin A (ConA) dimer from the open-state structure of kainate receptor GluK2 in complex with agonist glutamate and positive allosteric modulator BPAM344 bound to one ConA dimer. Type II interface between GluK2 ligand-binding domain and ConA
EMD-44124
Single-particle4.07 Å
Deposition: 18/03/2024Map released: 22/05/2024
Last modified: 26/06/2024
Sample Organism:
Canavalia ensiformis
Sample: Concanavalin-A dimer
Fitted models: 9b33
Deposition Authors: Nadezhdin KD
,
Gangwar SP ,
Sobolevsky AI ,
Sobolevsky AI
Sample: Concanavalin-A dimer
Fitted models: 9b33
Deposition Authors: Nadezhdin KD
,
Gangwar SP ,
Sobolevsky AI ,
Sobolevsky AI
Kainate receptor channel opening and gating mechanism.
Gangwar SP ,
Yelshanskaya MV,
Nadezhdin KD ,
Yen LY,
Newton TP ,
Aktolun M ,
Kurnikova MG ,
Sobolevsky AI
(2024) Nature , 630 , 762 - 768
,
Yelshanskaya MV,
Nadezhdin KD ,
Yen LY,
Newton TP ,
Aktolun M ,
Kurnikova MG ,
Sobolevsky AI
(2024) Nature , 630 , 762 - 768
Grant Support:
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): R01 NS083660 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): R01 NS107253 (United States)
- National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS): R01 AR078814 (United States)
- National Institutes of Health/National Cancer Institute (NIH/NCI): R01 CA206573 (United States)