Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-43966

Composite map
Single-particle
3.5 Å
EMD-43966
3D View Gallery
Deposition: 06/03/2024
Map released: 17/04/2024
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-43966
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9axf summary report (pdf.gz) Map and 9axf FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in detergent

EMD-43966

Composite map
Single-particle
3.5 Å
EMD-43966
3D View Gallery
Deposition: 06/03/2024
Map released: 17/04/2024
Last modified: 06/11/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus, Lama glama
Sample: Human CaSR in complex with chimeric Gq (miniGisq) protein
Fitted models: 9axf

Deposition Authors: Zuo H , Park J, Frangaj A , Ye J , Lu G, Manning JJ , Asher WB , Lu Z , Hu G, Wang L, Mendez J , Eng E, Zhang Z, Lin X, Grasucci R, Hendrickson WA , Clarke OB, Javitch JA , Conigrave AD , Fan QR
Promiscuous G-protein activation by the calcium-sensing receptor.
Zuo H , Park J, Frangaj A , Ye J , Lu G, Manning JJ , Asher WB , Lu Z , Hu GB , Wang L, Mendez J , Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA , Clarke OB, Javitch JA , Conigrave AD , Fan QR
(2024) Nature , 629 , 481 - 488
PUBMED: 38632411
DOI: doi:10.1038/s41586-024-07331-1
ISSN: 1476-4687
ASTM: NATUAS