EMD-43932

Single-particle
4.16 Å
EMD-43932
3D View Gallery
Deposition: 06/03/2024
Map released: 17/04/2024
Last modified: 10/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-43932

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9axc summary report (pdf.gz) Map-9axc FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Activated CRAF/MEK heterotetramer from focused refinement of CRAF/MEK/14-3-3 complex

EMD-43932

Single-particle
4.16 Å
EMD-43932
3D View Gallery
Deposition: 06/03/2024
Map released: 17/04/2024
Last modified: 10/07/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Activated CRAF/MEK1 heterotetramer complex from focused refinement
Fitted models: 9axc

Deposition Authors: Quade B , Cohen SE , Huang X
The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers.
Ryan MB , Quade B , Schenk N , Fang Z , Zingg M , Cohen SE , Swalm BM , Li C , Ozen A , Ye C , Ritorto MS , Huang X , Dar AC , Han Y , Hoeflich KP , Hale M , Hagel M
(2024) Cancer Discov , 14 , 1190 - 1205
PUBMED: 38588399
DOI: doi:10.1158/2159-8290.CD-24-0139
ISSN: 2159-8290
Grant Support: