Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-43746

Single-particle
3.1 Å
EMD-43746
3D View Gallery
Deposition: 20/02/2024
Map released: 31/07/2024
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-43746
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8w2f summary report (pdf.gz) Map and 8w2f FULL report (pdf.gz)
EMICSS annotations (xml)

Plasmodium falciparum 20S proteasome bound to an inhibitor

EMD-43746

Single-particle
3.1 Å
EMD-43746
3D View Gallery
Deposition: 20/02/2024
Map released: 31/07/2024
Last modified: 28/05/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Plasmodium falciparum 3D7
Sample: Plasmodium falciparum 20S proteasome bound with an inhibitor
Fitted models: 8w2f

Deposition Authors: Han Y, Deng X, Ray S, Chen Z, Phillips M
Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria.
Lawong A, Gahalawat S, Ray S, Ho N, Han Y, Ward KE, Deng X, Chen Z, Kumar A, Xing C , Hosangadi V, Fairhurst KJ, Tashiro K, Liszczak G, Shackleford DM , Katneni K, Chen G, Saunders J, Crighton E, Casas A, Robinson JJ , Imlay LS, Zhang X, Lemoff A , Zhao Z, Angulo-Barturen I, Jimenez-Diaz MB, Wittlin S, Campbell SF, Fidock DA, Laleu B , Charman SA , Ready JM, Phillips MA
(2024) Cell Chem Biol , 31 , 1503
PUBMED: 39084225
DOI: doi:10.1016/j.chembiol.2024.07.001
ISSN: 2451-9456