Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-43745
SARS-CoV-2 M protein dimer in complex with JNJ-9676 and Fab-B
EMD-43745
Single-particle3.06 Å
Deposition: 20/02/2024Map released: 29/01/2025
Last modified: 23/04/2025
Sample Organism:
Homo sapiens,
SARS-CoV-2 pseudovirus
Sample: Dimer complex of SARS-CoV-2 M protein with JNJ-9676 and Fab B
Fitted models: 8w2e
Deposition Authors: Yin Y, Van Damme E
Sample: Dimer complex of SARS-CoV-2 M protein with JNJ-9676 and Fab B
Fitted models: 8w2e
Deposition Authors: Yin Y, Van Damme E
A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein.
Van Damme E,
Abeywickrema P,
Yin Y,
Xie J,
Jacobs S 
,
Mann MK ,
Doijen J ,
Miller R,
Piassek M,
Marsili S,
Subramanian M,
Gottlieb L,
Abdelnabi R ,
Van Gool M ,
Van den Broeck N ,
De Pauw I,
Diels A,
Vermeulen P,
Temmerman K,
Scobey T,
Mattocks M ,
Schafer A ,
Jochmans D ,
De Jonghe S ,
Leyssen P ,
Chiu W ,
Diosa Toro M,
Zwaagstra M,
Leijs AA,
De Gruyter HLM,
Buyck C,
Van Den Heede K,
Jacobs F ,
Van den Eynde C,
Thijs L,
Raeymaekers V,
Miller S,
Del Rosario A ,
Neyts J ,
Peeters D,
Baric RS ,
van Kuppeveld FJM ,
Snijder EJ ,
van Hemert MJ,
Monshouwer M,
Sharma S ,
Draghia-Akli R ,
Koul A ,
Van Loock M
(2025) Nature , 640 , 506 - 513
,
Mann MK ,
Doijen J ,
Miller R,
Piassek M,
Marsili S,
Subramanian M,
Gottlieb L,
Abdelnabi R ,
Van Gool M ,
Van den Broeck N ,
De Pauw I,
Diels A,
Vermeulen P,
Temmerman K,
Scobey T,
Mattocks M ,
Schafer A ,
Jochmans D ,
De Jonghe S ,
Leyssen P ,
Chiu W ,
Diosa Toro M,
Zwaagstra M,
Leijs AA,
De Gruyter HLM,
Buyck C,
Van Den Heede K,
Jacobs F ,
Van den Eynde C,
Thijs L,
Raeymaekers V,
Miller S,
Del Rosario A ,
Neyts J ,
Peeters D,
Baric RS ,
van Kuppeveld FJM ,
Snijder EJ ,
van Hemert MJ,
Monshouwer M,
Sharma S ,
Draghia-Akli R ,
Koul A ,
Van Loock M
(2025) Nature , 640 , 506 - 513
Grant Support: