EMD-43738

Single-particle
2.28 Å
EMD-43738
3D View Gallery
Deposition: 19/02/2024
Map released: 09/07/2025
Last modified: 09/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-43738

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8w23 summary report (pdf.gz) Map-8w23 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of human tankyrase 2 SAM-PARP filament bound to compound, TDI-2804 (consensus map).

EMD-43738

Single-particle
2.28 Å
EMD-43738
3D View Gallery
Deposition: 19/02/2024
Map released: 09/07/2025
Last modified: 09/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Tankyrase 2 SAM-PARP filament bound to compound TDI-2804.
Fitted models: 8w23

Deposition Authors: Malone BF, Zimmerman JL, Dow LE, Hite RK
A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression.
Zimmerman J, Malone BF, Finkin-Groner E, Sun S, Liang R, Foronda M, Schatoff EM, Granowsky E, Goswami S, Katti A, Leach B, Alcorn H, Tammela T, Fukase Y, Khan T, Huggins DJ, Ginn J, Liverton N, Hite RK, Dow LE
(2025) bioRxiv
PUBMED: 40093088
DOI: doi:10.1101/2025.03.04.641305
ISSN: 2692-8205
Grant Support: