Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-43712
Human EBP complexed with compound 1
EMD-43712
Single-particle2.8 Å
Deposition: 14/02/2024Map released: 19/06/2024
Last modified: 19/06/2024
Sample Organism:
Homo sapiens
Sample: EBP complexed with compound 1
Fitted models: 8w0r
Deposition Authors: Sun D, Masureel M
Sample: EBP complexed with compound 1
Fitted models: 8w0r
Deposition Authors: Sun D, Masureel M
Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation.
Dorel R 
,
Sun D,
Carruthers N,
Castanedo GM ,
Ung PM ,
Factor DC ,
Li T,
Baumann H,
Janota D,
Pang J,
Salphati L,
Meklemburg R,
Korman AJ ,
Harper HE,
Stubblefield S,
Payandeh J,
McHugh D,
Lang BT,
Tesar PJ ,
Dere E,
Masureel M,
Adams DJ ,
Volgraf M,
Braun MG
(2024) J Med Chem , 67 , 4819 - 4832
,
Sun D,
Carruthers N,
Castanedo GM ,
Ung PM ,
Factor DC ,
Li T,
Baumann H,
Janota D,
Pang J,
Salphati L,
Meklemburg R,
Korman AJ ,
Harper HE,
Stubblefield S,
Payandeh J,
McHugh D,
Lang BT,
Tesar PJ ,
Dere E,
Masureel M,
Adams DJ ,
Volgraf M,
Braun MG
(2024) J Med Chem , 67 , 4819 - 4832
Grant Support: