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EMD-43674
Cryo-EM Structure of the BRAF V600E monomer
EMD-43674
Single-particle3.29 Å
Deposition: 09/02/2024Map released: 28/05/2025
Last modified: 25/06/2025
Sample Organism:
Homo sapiens
Sample: BRAF V600E - 14-3-3 complex
Fitted models: 8vyp
Deposition Authors: Lavoie H
,
Lajoie D ,
Jin T ,
Decossas M ,
Maisonneuve P ,
Therrien M
Sample: BRAF V600E - 14-3-3 complex
Fitted models: 8vyp
Deposition Authors: Lavoie H
,
Lajoie D ,
Jin T ,
Decossas M ,
Maisonneuve P ,
Therrien M
BRAF oncogenic mutants evade autoinhibition through a common mechanism.
Lavoie H ,
Jin T ,
Lajoie D ,
Decossas M ,
Gendron P ,
Wang B ,
Filandr F ,
Sahmi M ,
Jo CH ,
Weber S ,
Arseneault G ,
Tripathy S,
Beaulieu P,
Schuetz DA ,
Schriemer DC ,
Marinier A ,
Rice WJ ,
Maisonneuve P ,
Therrien M
(2025) Science , 388 , eadp2742 - eadp2742
,
Jin T ,
Lajoie D ,
Decossas M ,
Gendron P ,
Wang B ,
Filandr F ,
Sahmi M ,
Jo CH ,
Weber S ,
Arseneault G ,
Tripathy S,
Beaulieu P,
Schuetz DA ,
Schriemer DC ,
Marinier A ,
Rice WJ ,
Maisonneuve P ,
Therrien M
(2025) Science , 388 , eadp2742 - eadp2742
Grant Support: