EMD-43558

Single-particle
3.3 Å
EMD-43558
3D View Gallery
Deposition: 31/01/2024
Map released: 15/01/2025
Last modified: 13/08/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-43558

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-8vvg summary report (pdf.gz) Map-8vvg FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Kappa opioid receptor in complex with heterotrimerig Gi protein, bound to inverse agonist GB18

EMD-43558

Single-particle
3.3 Å
EMD-43558
3D View Gallery
Deposition: 31/01/2024
Map released: 15/01/2025
Last modified: 13/08/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Kappa opioid receptor in complex with heterotrimeric G protein (Gai/b/g) and inverse agonist JDTic
Fitted models: 8vvg

Deposition Authors: Gati C , Motiwala Z , Tyson AS, Styrpejko D, Han GW, Khan S, Ramos-Gonzalez N , Shenvi R , Majumdar S
Molecular mechanisms of inverse agonism via kappa-opioid receptor-G protein complexes.
Tyson AS, Khan S, Motiwala Z , Han GW, Zhang Z, Ranjbar M, Styrpejko D, Ramos-Gonzalez N , Woo S , Villers K, Landaker D , Kenakin T , Shenvi R , Majumdar S , Gati C
(2025) Nat Chem Biol , 21 , 1046 - 1057
PUBMED: 39775170
DOI: doi:10.1038/s41589-024-01812-0
ISSN: 1552-4469