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EMD-43476
Structure of Mycobacterium smegmatis 50S ribosomal subunit bound to HflX and erythromycin:50S-HflX-A-Ery
EMD-43476
Single-particle2.8 Å
Deposition: 20/01/2024Map released: 19/02/2025
Last modified: 30/04/2025
Sample Organism:
Mycolicibacterium smegmatis MC2 155
Sample: Mycobacterium smegmatis 50S ribosome bound to HflX-GMPPCP complex and Erythromycin
Fitted models: 8vr4
Deposition Authors: Majumdar S
,
Koripella RK,
Sharma MR ,
Manjari SR,
Banavali NK ,
Agrawal RK
Sample: Mycobacterium smegmatis 50S ribosome bound to HflX-GMPPCP complex and Erythromycin
Fitted models: 8vr4
Deposition Authors: Majumdar S
,
Koripella RK,
Sharma MR ,
Manjari SR,
Banavali NK ,
Agrawal RK
HflX-mediated drug resistance through ribosome splitting and rRNA disordering in mycobacteria.
Majumdar S ,
Kashyap A,
Koripella RK,
Sharma MR ,
Hurst-Hess K,
Manjari SR,
Banavali NK ,
Ghosh P,
Agrawal RK
(2025) PNAS , 122 , e2419826122 - e2419826122
,
Kashyap A,
Koripella RK,
Sharma MR ,
Hurst-Hess K,
Manjari SR,
Banavali NK ,
Ghosh P,
Agrawal RK
(2025) PNAS , 122 , e2419826122 - e2419826122
Grant Support:
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): R01Al1554732 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R01 GM61576 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): R01AI132422 (United States)