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EMD-43386

Single-particle
3.77 Å
EMD-43386
3D View Gallery
Deposition: 15/01/2024
Map released: 04/12/2024
Last modified: 18/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-43386
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8voj summary report (pdf.gz) Map and 8voj FULL report (pdf.gz)
EMICSS annotations (xml)

The Cryo-EM structure of LSD1-CoREST-HDAC1 in complex with KBTBD4 enhanced by UM171 and IP6

EMD-43386

Single-particle
3.77 Å
EMD-43386
3D View Gallery
Deposition: 15/01/2024
Map released: 04/12/2024
Last modified: 18/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: LHC-K4
Fitted models: 8voj

Deposition Authors: Xie X , Mao H, Liau B, Zheng N
UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors.
Yeo MJR , Zhang O , Xie X , Nam E, Payne NC , Gosavi PM , Kwok HS , Iram I , Lee C , Li J, Chen NJ , Nguyen K , Jiang H , Wang ZA , Lee K , Mao H, Harry SA, Barakat IA, Takahashi M , Waterbury AL , Barone M , Mattevi A , Carr SA , Udeshi ND , Bar-Peled L , Cole PA , Mazitschek R , Liau BB , Zheng N
(2025) Nature , 639 , 232 - 240
PUBMED: 39939761
DOI: doi:10.1038/s41586-024-08532-4
ISSN: 1476-4687
ASTM: NATUAS
Grant Support: