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EMD-42676
5-HT2AR bound to Lisuride in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM)
EMD-42676
Composite mapSingle-particle
2.8 Å
Deposition: 06/11/2023Map released: 29/05/2024
Last modified: 13/11/2024
Sample Organism:
Homo sapiens
Sample: 5-HT2AR bound to Lisuride in complex with heterotrimeric mini-Gq protein and single-chain variable fragment (scFv16)
Fitted models: 8uwl
Deposition Authors: Barros-Alvarez X
,
Kim K ,
Panova O,
Roth BL ,
Skiniotis G
Sample: 5-HT2AR bound to Lisuride in complex with heterotrimeric mini-Gq protein and single-chain variable fragment (scFv16)
Fitted models: 8uwl
Deposition Authors: Barros-Alvarez X
,
Kim K ,
Panova O,
Roth BL ,
Skiniotis G
AlphaFold2 structures guide prospective ligand discovery.
Lyu J ,
Kapolka N ,
Gumpper R,
Alon A ,
Wang L ,
Jain MK ,
Barros-Alvarez X ,
Sakamoto K ,
Kim Y,
DiBerto J ,
Kim K ,
Glenn IS ,
Tummino TA ,
Huang S,
Irwin JJ ,
Tarkhanova OO ,
Moroz Y ,
Skiniotis G ,
Kruse AC ,
Shoichet BK ,
Roth BL
(2024) Science , 384 , eadn6354 - eadn6354
,
Kapolka N ,
Gumpper R,
Alon A ,
Wang L ,
Jain MK ,
Barros-Alvarez X ,
Sakamoto K ,
Kim Y,
DiBerto J ,
Kim K ,
Glenn IS ,
Tummino TA ,
Huang S,
Irwin JJ ,
Tarkhanova OO ,
Moroz Y ,
Skiniotis G ,
Kruse AC ,
Shoichet BK ,
Roth BL
(2024) Science , 384 , eadn6354 - eadn6354
Grant Support:
- Defense Advanced Research Projects Agency (DARPA): HR001119S0092 (United States)