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EMD-42625
Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC804515)
EMD-42625
Single-particle3.22 Å
Deposition: 03/11/2023Map released: 21/08/2024
Last modified: 21/08/2024
Sample Organism:
Homo sapiens
Sample: p97/VCP AAA+ ATPase R155H mutant/NSC804515
Fitted models: 8uvo
Deposition Authors: Nandi P
,
DeVore K,
Chiu P-L
Sample: p97/VCP AAA+ ATPase R155H mutant/NSC804515
Fitted models: 8uvo
Deposition Authors: Nandi P
,
DeVore K,
Chiu P-L
Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors.
Nandi P ,
DeVore K,
Wang F,
Li S,
Walker JD,
Truong TT ,
LaPorte MG,
Wipf P ,
Schlager H,
McCleerey J ,
Paquette W ,
Columbres RCA ,
Gan T,
Poh YP,
Fromme P,
Flint AJ,
Wolf M,
Huryn DM,
Chou TF ,
Chiu PL
(2024) Commun Chem , 7 , 177 - 177
,
DeVore K,
Wang F,
Li S,
Walker JD,
Truong TT ,
LaPorte MG,
Wipf P ,
Schlager H,
McCleerey J ,
Paquette W ,
Columbres RCA ,
Gan T,
Poh YP,
Fromme P,
Flint AJ,
Wolf M,
Huryn DM,
Chou TF ,
Chiu PL
(2024) Commun Chem , 7 , 177 - 177
Grant Support:
- National Institutes of Health/National Cancer Institute (NIH/NCI): (United States)