EMD-42491

Single-particle
4.4 Å
EMD-42491
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Deposition: 25/10/2023
Map released: 14/08/2024
Last modified: 11/09/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-42491
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CryoEM Structure of Allosterically Switchable De Novo Protein sr312, in Open State with Effector Peptide

EMD-42491

Single-particle
4.4 Å
EMD-42491
3D View Gallery
Deposition: 25/10/2023
Map released: 14/08/2024
Last modified: 11/09/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: synthetic construct
Sample: Complex is comprised of 4 sr312 proteins, each sr312 protein is bound to an effector peptide, putting the protein in an open state. Complex is formed with C4 symmetry.
Fitted models: 8ure

Deposition Authors: Weidle C, Skotheim R
De novo design of allosterically switchable protein assemblies.
Pillai A , Idris A, Philomin A , Weidle C, Skotheim R , Leung PJY, Broerman A , Demakis C, Borst AJ , Praetorius F , Baker D
(2024) Nature , 632 , 911 - 920
PUBMED: 39143214
DOI: doi:10.1038/s41586-024-07813-2
ISSN: 1476-4687
ASTM: NATUAS
Grant Support: