EMD-42463
Alzheimer's disease PHF complexed with PET ligand MK-6240
EMD-42463
Helical reconstruction2.31 Å
Deposition: 23/10/2023Map released: 04/09/2024
Last modified: 23/10/2024
Sample Organism:
Homo sapiens
Sample: Microtubule-associated protein tau
Fitted models: 8uq7
Deposition Authors: Kunach P
,
Shahmoradian SH ,
Diamond MI ,
Rosa-Neto P
Sample: Microtubule-associated protein tau
Fitted models: 8uq7
Deposition Authors: Kunach P
,
Shahmoradian SH ,
Diamond MI ,
Rosa-Neto P
Cryo-EM structure of Alzheimer's disease tau filaments with PET ligand MK-6240.
Kunach P ,
Vaquer-Alicea J ,
Smith MS,
Monistrol J ,
Hopewell R,
Moquin L,
Therriault J ,
Tissot C ,
Rahmouni N,
Massarweh G,
Soucy JP,
Guiot MC,
Shoichet BK ,
Rosa-Neto P ,
Diamond MI ,
Shahmoradian SH
(2024) Nat Commun , 15 , 8497 - 8497
,
Vaquer-Alicea J ,
Smith MS,
Monistrol J ,
Hopewell R,
Moquin L,
Therriault J ,
Tissot C ,
Rahmouni N,
Massarweh G,
Soucy JP,
Guiot MC,
Shoichet BK ,
Rosa-Neto P ,
Diamond MI ,
Shahmoradian SH
(2024) Nat Commun , 15 , 8497 - 8497
Grant Support:
- Cancer Prevention and Research Institute of Texas (CPRIT): RP170644 (United States)
- National Institutes of Health/National Institute of Mental Health (NIH/NIMH): R35GM122481 (United States)
- Canadian Institutes of Health Research (CIHR): MOP-11-51-31 (Canada)
- Canadian Institutes of Health Research (CIHR): 152985 (Canada)