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EMD-42247
Degrader-induced complex between PTPN2 and CRBN-DDB1
EMD-42247
Single-particle3.3 Å
Deposition: 06/10/2023Map released: 11/09/2024
Last modified: 11/09/2024
Sample Organism:
Homo sapiens
Sample: CRBN-DDB1-PTPN2 complex
Fitted models: 8uh6
Deposition Authors: Catalano C
,
Bratkowski M ,
Scapin G,
Hao Q
Sample: CRBN-DDB1-PTPN2 complex
Fitted models: 8uh6
Deposition Authors: Catalano C
,
Bratkowski M ,
Scapin G,
Hao Q
Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex.
Hao Q ,
Rathinaswamy MK,
Klinge KL,
Bratkowski M ,
Mafi A,
Baumgartner CK,
Hamel KM,
Veits GK,
Jain R,
Catalano C ,
Fitzgerald M,
Hird AW,
Park E,
Vora HU,
Henderson JA,
Longenecker K,
Hutchins CW,
Qiu W,
Scapin G,
Sun Q,
Stoll VS,
Sun C,
Li P,
Eaton D ,
Stokoe D,
Fisher SL,
Nasveschuk CG ,
Paddock M,
Kort ME
(2024) Commun Chem , 7 , 183 - 183
,
Rathinaswamy MK,
Klinge KL,
Bratkowski M ,
Mafi A,
Baumgartner CK,
Hamel KM,
Veits GK,
Jain R,
Catalano C ,
Fitzgerald M,
Hird AW,
Park E,
Vora HU,
Henderson JA,
Longenecker K,
Hutchins CW,
Qiu W,
Scapin G,
Sun Q,
Stoll VS,
Sun C,
Li P,
Eaton D ,
Stokoe D,
Fisher SL,
Nasveschuk CG ,
Paddock M,
Kort ME
(2024) Commun Chem , 7 , 183 - 183
Grant Support: