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EMD-42151
Structure of the P1B7 antibody bound to the Sotorasib-modified KRas G12C peptide presented by the A*03:01 MHC I complex
EMD-42151
Single-particle3.1 Å
Deposition: 28/09/2023Map released: 16/10/2024
Last modified: 14/05/2025
Sample Organism:
Homo sapiens
Sample: P1B7 antibody:V7-Sotorasib A*03:01 MHC I complex
Fitted models: 8udr
Deposition Authors: Chan LM
,
Roweder PJ,
Craik CS ,
Verba KA
Sample: P1B7 antibody:V7-Sotorasib A*03:01 MHC I complex
Fitted models: 8udr
Deposition Authors: Chan LM
,
Roweder PJ,
Craik CS ,
Verba KA
Therapeutic Targeting and Structural Characterization of a Sotorasib-Modified KRAS G12C-MHC I Complex Demonstrate the Antitumor Efficacy of Hapten-Based Strategies.
Pandey A ,
Rohweder PJ ,
Chan LM ,
Ongpipattanakul C ,
Chung DH ,
Paolella B ,
Quimby FM ,
Nguyen N ,
Verba KA ,
Evans MJ ,
Craik CS
(2025) Cancer Res. , 85 , 329 - 341
,
Rohweder PJ ,
Chan LM ,
Ongpipattanakul C ,
Chung DH ,
Paolella B ,
Quimby FM ,
Nguyen N ,
Verba KA ,
Evans MJ ,
Craik CS
(2025) Cancer Res. , 85 , 329 - 341
Grant Support:
- National Institutes of Health/National Cancer Institute (NIH/NCI): P41-GM103393 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): T32 GM 064337 (United States)
- Howard Hughes Medical Institute (HHMI): (United States)